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Post by sj on Jan 30, 2005 4:19:34 GMT 1
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Post by rivenwil on Jul 28, 2005 12:41:04 GMT 1
I fully vaccinate my dogs (i.e. I do not 'split' shots) and, touch wood, have never had an adverse vaccine reaction. I take the stance that dogs that do react have a compromised immune system and therefore should not be bred from. That is a hardline stance I know, but there seems to be more and more immune-related disorders in the breed (or perhaps vets are more aware these days and diagnosing immune-related disorders more readily) and I want to do what I can to maintain health.
The results of one United Kingdom-based study on a group of 25 Weimaraners apparently suffering from immune dysfunction is published in this article in Vet Record:
Foale et al., 2003, Vet. Record v. 153 No. 18
I have a copy of the article on my website if you can't google it (under health issues), but I could post it here if requested.
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Post by rivenwil on Jul 28, 2005 12:54:01 GMT 1
Abstract of article on 25 Weimaraners with apparent immune disorder (referenced in previous post).
Abstract:
Twenty-five weimaraners with recurrent infections or inflammatory disease were investigated; their median age was four months (range two to 36 months), and 11 of them were male and 14 female. Twenty of them showed signs of lethargy, anorexia or pyrexia, 13 had been vomiting or had diarrhoea, 12 had shown signs of pain in the joints or bones and been lame, five had had reactions at the site of an injection, five had generalised lymphadenopathy, three had urinary tract infections and two had recurrent or severe pyoderma. They all had a lower concentration of one or more classes of serum immunoglobulin (IgG, IgM and IgA) than the standard control ranges, and their mean concentration of IgG was significantly lower (P<0·005) than the mean concentration of IgG in 15 clinically normal weimaraners. Of 10 cases for which a complete vaccination history was available, nine had developed clinical signs within five days of being vaccinated. Follow-up data were available from 21 of the 25 dogs for a median period of 24·5 months. One dog died during a symptomatic episode, three were euthanased, six were alive at follow-up but had continued to show clinical signs and 11 had made a full recovery.
Keywords: Weimaraner; immunodeficiency; immunoglobulin; inflammatory disease; recurrent infection
Document Type: Research article
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Post by rivenwil on Jul 28, 2005 13:00:56 GMT 1
Another article!
Development of hypertrophic osteodystrophy and antibody response in a litter of vaccinated Weimaraner puppies
Authors: Harrus S.; Waner T.; Aizenberg I.; Safra N.; Mosenco A.; Radoshitsky M.; Bark H.
Source: The Journal of Small Animal Practice, Volume 43, Number 1, 31 January 2002, pp. 27-31(5)
Publisher: BVA Publications
Abstract:
Two different vaccination protocols were compared with regard to the development of hypertrophic osteodystrophy (HOD) (also termed metaphyseal osteopathy) and effectiveness of immunisation in a litter of 10 Weimaraner puppies. Five puppies (group 1) were vaccinated with a modified live canine parvovirus vaccine (CPV) and then two weeks later with a trivalent vaccine containing modified live canine distemper virus and adenovirus type 2 combined with a Leptospira bacterin (DHL). The CPV and DHL vaccine protocols were administered a further two times, at two-week intervals. Group 2 was vaccinated with three consecutive multivalent vaccines containing modified live canine distemper virus, canine parvovirus, parainfluenza and adenovirus type 2 combined with a Leptospira bacterin, at four-week intervals. All puppies were first vaccinated at the age of eight weeks. Three dogs in group 1 developed HOD, while all five dogs in group 2 developed HOD during the study period. Dogs in group 2 had more episodes of HOD than those in group 1. Dogs in group 1 developed higher antibody titres to canine distemper virus and parvovirus compared with those in group 2. Only two out of the 10 dogs developed protective antibody titres to parvovirus. The results of this study suggest that the two different vaccination protocols affected the pattern of appearance of HOD and immunisation in this litter of Weimaraner puppies. The results obtained and the previously reported data suggest that a larger controlled study is needed to further elucidate the effect of different vaccination protocols on HOD and immunisation in Weimaraner puppies.
Keywords: Hypertrophic osteodystrophy; dogs; vaccination; antibody response
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Post by Alkemist on Jul 29, 2005 20:10:31 GMT 1
I don't know if this is the type of response required on the thread, but so far in the UK with my dogs I have completed the puppy course of combined vaccinations. I have then switched to homeopathic nosodes and used those in place of boosters. No scientific proof here, just what I feel is right, but TBH I haven't thought that maybe the best thing to do is go as normal and exclude any reacting dogs from a breeding programme. In my search for info on MCT's, I read an article that listed vaccinations as a possible cause of the increase in Mast Cell Tumours, but as Jensen had his appear at 7-8 weeks, and was unvaccinated at the time, I can't add to that.
Nina
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